About Nijmegen Breakage Syndrome

Nijmegen breakage syndrome (NBS), is a rare genetic disorder that is characterized by a small head size (microcephaly), immunodeficiency (weakened immune system), increased sensitivity to the effects of radiation exposure including medical x-rays and an increased risk of developing cancer, especially lymphoma or leukemia. Cancer treatment must be modified because conventional doses of chemotherapy may lead to severe even lethal life-threatening toxic complications.

Since NBS patients are immunocompromised, they have an increased risk of developing infections (especially respiratory tract infections).

NBS patients are born with a mutated gene that normally codes for a protein called nibrin. Nibrin helps repair DNA that has been damaged by chromosome breaks. Therefore, NBS patients are susceptible to chromosomal breakage, which leads to rearrangements of translocations. In other words, one piece of a chromosome is broken off and joined to another chromosome. Chromosomal rearrangements typically occur in chromosomes 7 and 14, both of which are involved in the development of the immune system.

The syndrome is named after the city Nijmegen in the Netherlands, where the first case of NBS was described in 1998.

The disorder is extremely rare. Most NBS patients are of Slavic or other European decent. Men and women are affected equally.

Rare is the reason there is not enough research being done.

Rare is the reason there is so little funding.

Rare is why our kids don’t have more option.

Spread Awareness

Rare diseases collectively affect millions of children. They often are serious, debilitating and life altering; many are life threatening as fatal. These children desperately need treatments, cures and answers. A cure for genetic disorder may not come easily but treatments are very much needed.

This is why they need your help.

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There are countless ways to get involved with Mia’s Dream Foundation. Join the Fight to help raise funds for research.
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There are many ways for you to join the Mia’s Dream Foundation team and make a donation. Every dollar raised benefit research needed to find a cure. You can choose to make Mia’s Dream Foundation your charity of choice. Through a one-time monetary donation or a recurring donation.
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OUR MISSION

something bigger

OUR MISSION

The mission of Mia’s Dream Foundation is to raise funds for pediatric cancer research to find better, safer and less toxic treatment options for children with cancer, as well as support the development of a formal treatment for Nijmegen Breakage Syndrome Disease by funding research and raising awareness.
Our Mission